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According to most experts, Estriol is considered the most effective and safest estrogen. All the available evidence indicates that estriol is the safest estrogen to use to control menopausal symptoms. Estrogen deficiency can cause vaginal dryness and atrophy, which predisposes a woman to vaginitis and cystitis. Geromatrix® ProEstro^TM topical skin cream, could theoretically, be an effective and safe estrogen to use. If you have symptoms such as hot flashes and night sweats, you can try Estriol daily and experiment to find the smallest dose that will maintain balance. If you are experiencing vaginal dryness, very small amounts of Estriol cream used once or twice a week may effectively stop that problem.

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Estriol should always be accompanied by progesterone. Geromatrix® ProEstro^TM Cream, a topical skin cream, should be used in conjunction of Geromatrix® BioProgest^TM topical skin cream for female endocrine balance.  ProEstro^TM Cream is a revolutionary product featuring the new "LIPOSOME" technology, which fills billions of microscopic time-released "bubbles" with natural Estriol. It is plant-based, has no animal products or by-products, and uses no animal testing. One of the most exciting things about estriol is the fact that not only does it not promote breast cancer, but considerable evidence exists to show that it protects against this disease.

Natural Estrogen (Natural Estriol USP) vs. Synthetic Estrogen (Conjugated)

Natural Estriol is developed through DNA technology. Sterol analogues found in many varieties of plants (wild yam) are combined with specific bacteria (microbial fermentation) and the resulting molecule is bio-identical in chemical structure to the estriol produced by the human body. There are no animal or human products or by-products. Conjugated equine estrogen, a synthetic estrogen that is the most commonly prescribed estrogen supplements in the United States, has been linked to increased cancer rates. Premarin®, Prempro®, Premphase® and Prempac® are conjugated equine estrogen being synthesized from pregnant mare's urine.

Following excerpts are from "Estriol, the Forgotten Estrogen?" from The Journal of the American Medical Association.

In our country it has been labeled as a weak or ineffective estrogen and difficult if not impossible to obtain. Actually it is not weak if given in adequate doses. A dose of *2 to 4 mg is the equivalent of .6 to 1.25 mg of conjugated estrogen or estrone and is just as effective. It has been available in Europe for many years. Importantly, estriol does not lose its unique identity, as does estradiol. It remains estriol. Lemon, reporting on chemically induced rat mammary carcinoma, demonstrated a notable inhibition of mammary carcinogens with estriol therapy compared with therapy using estrone and estradiol. According to an unpublished study by Henry M. Lemon, John F. Foley, and M. Anne Kessinger, 2.5 to 5 mg of estriol, equivalent to a little more than .65 and 1.25 mg of conjugated estrogens were used, with the informed consent of patients, in postmenopausal women with breast carcinoma and metastases. The preliminary investigation was initiated as a trial of the safety and estrogenicity of the hormone in postmenopausal women with breast cancer and not primarily to test its activity as an alternative therapeutic estrogen for breast cancer. Thirty-seven percent receiving this small dosage had remission or arrest of metastatic lesions.

Following excerpts are from Health and Healing by Dr. Julian Whitaker MD:

Estriol's anti-cancer effect is thought to be due to its anti-estrone characteristics. It apparently blocks the stimulatory effect of estrone on the breast. Estriol is weaker in that it requires *2 to 4 mg of estriol to equal the effects of 0.6 to 1.25 mg of Premarin. But that is inconsequential when one considers that the more estriol a woman takes, the less likely she gets breast cancer, which is exactly the opposite of the dosage relationships of commonly used estrogens. (*note: oral estriol)

Following excerpts are from "What Your Doctor May Not Tell You About Menopause" by Dr. John R. Lee, MD:

If a three-month trial of progesterone plus proper diet and supplements of magnesium and B6 do not relieve hot flashes or vaginal dryness, then low-dose natural estrogen may be helpful. All the available evidence we have so far indicates that estriol is the safest estrogen to use to control menopausal symptoms, and that it may even be protective against breast cancer. If you need to supplement some estrogen, you can use a natural estrogen in a cream: 1 to 4 mg daily for estriol. We can't emphasize strongly enough that no women, with or without a uterus or ovaries, should ever take estrogen alone. It should always be **combined with natural progesterone. (*In the quote "2-4 mg" of estriol, they are speaking of oral use not topical).
**Combined means use natural progesterone crème in the same month that natural estriol crème is used.

Ingredients:

• 50 mg Micronized Natural Estriol USP
• Purified Water
• Lanol (Coco Caprylate/Caprate from vegetable) origin)
• Montanov68 (Cetearylglucoside from vegetable origin)
• Natural Omega Oils (Safflower, Hemp, Evening Primrose)
• Phospholipids (natural liposome carrier system)
• Grapefruit Seed Extract
• Capryloyl Glycin/Undecylenoyl Glycin (vegetable origin antimicrobial)
• Potassium Sorbate (powder from ash trees and potassium salt)
• Fragrance Free

Directions:

• Apply to clean skin
• Use between 1-4 milligrams
• Start with 1/4 teaspoon (1 milligram) three times a week or as recommended by a health care professional
• Rotate areas daily
• Not to be used during pregnancy or lactation
• Always use in combination with Geromatrix® Micronized BioProgest Creme
• Each 1/4 tsp provides 1 milligram Micronized Natural Estriol USP

Each jar contains:

• 2 oz.

All information compiled is strictly for educational purposes and Geromatrix® Nutraceutical Corporation is not responsible for this information. It is recommended to consult with a health professional. The FDA has not evaluated these statements. Information is not intended to diagnose, treat, cure or prevent disease. Consult a health professional.